Mechanoenzymatik: Atomistische Simulation biomolekularer Nanomaschinen

Prof. Dr. Helmut Grubmüller, Max-Planck-Institut für biophysikalische Chemie, Göttingen

3 Feb 2012, 17:15; Location: S2|14-024

Proteins are biological nanomachines. Virtually every function in the cell is carried out by proteins - ranging from protein synthesis, ATP synthesis, molecular binding and recognition, selective transport, sensor functions, mechanical stability, and many more.

The combined interdisciplinary efforts of the past years have revealed how many of these functions are effected on the molecular level.

Computer simulations of the atomistic dynamics play a pivotal role in this enterprise, as they offer both unparalleled temporal and spacial re-solution. With state of the art examples, this talk will explain the basics of this high performance computing method, the type of questions that can (and cannot) be addressed, and its current limitations.

The examples include the mechanical force sensor titin kinase, mechanics of FATP synthase, and the flexible recognition by nuclear pore transporters.

This talk is provided together with the Physics Colloquium at TU Darmstadt.

Category: CE Seminar


Technische Universität Darmstadt

Graduate School CE
Dolivostraße 15
D-64293 Darmstadt

Phone+49 6151/16-24401
Fax -24404

to assistants' office

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